Darth Plagueis is not the only one able to manipulate midi-chlorians, but he took it to a new level

What are midi-chlorians?

Without the midi-chlorians, life could not exist, and we would have no knowledge of the Force. They continually speak to us, telling us the will of the Force. When you learn to quiet your mind, you'll hear them speaking to you.
QUI-GON JINN, TO ANAKIN SKYWALKER

What is midi-chlorian manipulation?

Plagueis was finally learning to do that, and was just beginning to learn how to persuade, prompt, cajole, and coax them into action. Already he could command them to promote healing

Darth Plagueis

Sidious was apprentice to Darth Plagueis, a wise Sith Lord whose knowledge of arcane and unnatural arts was reputed to extend to manipulating the very essence of life.

StarWars.com Databank: Sith

On the same day they had allowed Venamis to die. Then, by manipulating the Bith’s midi-chlorians, which should have been inert and unresponsive, Plagueis had resurrected him. The enormity of the event had stunned Sidious into silence and overwhelmed and addled 11-4D’s processors, but Plagueis had carried on without assistance, again and again allowing Venamis to die and be returned to life, until the Bith’s organs had given out and Plagueis had finally granted him everlasting death.

Darth Plagueis

Now, let's see other statements which allude to midi-chlorian manipulation.


Essence transfer is the secret of eternal life. The physical body will always weaken and fail, yet it is nothing but a shell or vessel. When it is time, it is possible to transfer your consciousness—your spirit—into a new vessel…
DARTH ANDEDDU

When you transfer your soul into another vessel; you influence
the host's midi-chlorians as well. Your dark presence will corrupt them.

Then we have the matter of Dark Transfer. Krayt uses it on Cade and kills him, then brings him back to life.

And then we have Muur's rakghouls. Exar Kun's terentateks.

All these were done by influencing midi-chlorians and manipulating them.

In fact the book admits the fact that ancient Sith could have been capable of doing what Plagueis has done if not for their fumbling ignorance of the Cosmic Force.

In the same way that the pre-Bane Sith had been responsible for their own extinction, the great dark side Lords of the past had doomed themselves to the nether realm through their attempts to conquer death by feeding off the energies of others, rather than by tapping the deepest strata of the Force and learning to speak the language of the midi-chlorians.

Darth Plagueis

Very cool. I like that you compared the different methods in which Sith seek eternal life.

Marc Spector wrote:Very cool. I like that you compared the different methods in which Sith seek eternal life.

Midi-chlorian manipulation is overrated. Just saying...